CFR of invasive pneumococcal disease in children in LMICs range from 20% for septicaemia to 50% for meningitis. There are up to 25% long-term neurological sequelae (hearing loss, mental retardation, motor abnormalities) in survivors of childhood pneumococcal meningitis. Go to footnote 1 The CFR for bacteremic pneumococcal pneumonia is 5-7% in areas with good access to medical treatment, but can be higher in areas in whic access to care and treatment is more limited. Go to footnote 2
- Go back to footnote reference 1
Edmond K, Clark A, Korczak VS, Sanderson C, Griffiths UK et al. (2010). Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. Lancet Infect Dis. 10(5):317–328. doi: 10.1016/S1473-3099(10)70048-7.
- Go back to footnote reference 2
Public Health Agency of Canada (2023). Invasive Pneumococcal Disease: For Health Professionals. Government of Canada. (https://www.canada.ca/en/public-health/services/immunization/vaccine-preventable-diseases/invasive-pneumococcal-disease/health-professionals.html, accessed 16 September 2025).
