The SYSVAC registry includes a variety of systematic reviews, including living, rapid, and umbrella reviews. It allows users to search for reviews using free text and keywords (e.g., disease/pathogen, population). Reviews in the registry have been assessed for quality, using the AMSTAR 2 (A MeaSurement Tool to Assess systematic Reviews 2) appraisal tool.
To include the most relevant systematic reviews in the field, registry staff conduct weekly searches of multiple databases, including Medline, Embase, The Cochrane Library, and different pre-print servers. For the December 2020 launch of the registry, priority has been given to systematic reviews related to COVID-19. Systematic reviews covering more diseases/pathogens will be added in 2021.