Hexavalent vaccines

The acceptability of child combination vaccination including DTP, HepB, Hib and polio vaccination, varies globally and is influenced by factors such as cultural beliefs, misinformation, relationships between parents and healthcare professionals, and perceived disease risk.^{Go to footnote 11, Go to footnote 22, Go to footnote 33, Go to footnote 44, Go to footnote 55}

Evidence from Malaysia suggests that acceptability of introducing a fully liquid hexa-aP vaccine is also influenced by perceptions of vaccine safety, reduced number of injections, convenience, and confidence in the immunization programme.^{Go to footnote 33}

DTP vaccine acceptance was high among parents in France (85%) and India (98%).^{Go to footnote 44}

Pertussis vaccine acceptance in countries such as the United Kingdom, Italy, Ireland, Australia, West Germany and Russia has been influenced by adverse events and to lesser extent the low effectiveness of selected wP vaccines.^{Go to footnote 55}

In polio endemic regions, vaccine resistance has been linked to misconceptions about vaccine safety and cultural opposition, despite awareness of the disease's severity. Conversely, in polio-free countries, vaccine acceptability is generally high, though complacency has led to gaps in coverage, as evidenced by recent vaccine-derived poliovirus (cVDPV) outbreaks in the United Kingdom and Israel. Addressing these challenges, global initiatives led by WHO, UNICEF, and the Global Polio Eradication Initiative (GPEI) have prioritized public education and community engagement to sustain vaccination acceptance and achieve eradication goals.^{Go to footnote 11, Go to footnote 22}