Hepatitis B birth dose vaccines comparison
ExportBiological E. Limited
LG Chem Ltd
GlaxoSmithKline
Centro de Ingenieria Genetica y Biotecnologia
Serum Institute of India
India
Republic of Korea
Belgium
Cuba
India
2013
1996
1986
1990
2000
2025
2020
1987
2001
2004
N/A
HBsAg
HBsAg
HBsAg
HBsAg
Recombinant HBsAg
Recombinant HBsAg
Recombinant HBsAg
Recombinant HBsAg
Recombinant HBsAg
Pichia pastoris
Saccharomyces cerevisiae
Saccharomyces cerevisiae
Pichia pastoris
Hansenula polymorpha
Aluminium hydroxide
Aluminium hydroxide
Aluminium hydroxide
Aluminium hydroxide
Aluminium hydroxide
None for 1-dose
Thiomersal for 10-dose
Thiomersal
None for 1-dose
Thiomersal for 10-dose
Thiomersal
Thiomersal
Not required
Not required
Not required
Not required
Not required
Liquid ready-to-use
Liquid ready-to-use
Liquid ready-to-use
Liquid ready-to-use
Liquid ready-to-use
1-dose vial
10-dose vial
1-dose vial
10-dose vial
1-dose vial and prefilled syringe
1-dose vial
10-dose vial
1-dose vial and ampoule
10-dose vial
Intramuscular
Intramuscular
Intramuscular
Intramuscular
Intramuscular
36 months
36 months
24 months
48 months
36 months
2–8 °C
2–8 °C
2–8 °C
2–8 °C
2–8 °C
Type 30
Type 30
None
Type 30
Type 30
1-dose: 14.68 (carton of 48 vials)
10-dose: 4.06 (carton of 24 vials)
1-dose: 14.53 (carton of 10 vials)
10-dose: 2.86 (carton of 10 vials)
Information not available
10-dose vials: 2.76
1-dose 4 ml vial: 17.575
1-dose 2 ml vial: 14.06
1-dose ampoule: 12.18
10-dose vial: 2.109
Birth dose followed by 2–3 doses, starting at 6 weeks with minimum 4 weeks interval between doses 2–4
Birth dose followed by 2–3 doses, starting at 6 weeks with minimum 4 weeks interval between doses 2–4
Birth dose followed by 2–3 doses, starting at 6 weeks with minimum 4 weeks interval between doses 2–4
Birth dose followed by 2–3 doses, starting at 6 weeks with minimum 4 weeks interval between doses 2–4
Birth dose followed by 2–3 doses, starting at 6 weeks with minimum 4 weeks interval between doses 2–4
Yes
Yes
Yes
Yes
Yes
Not required in healthy people
Not required in healthy people
Not required in healthy people
Not required in healthy people
Not required in healthy people
No specific safety concerns with a birth dose
No specific safety concerns with a birth dose
No specific safety concerns with a birth dose
No specific safety concerns with a birth dose
No specific safety concerns with a birth dose
Yes
Yes
Vaccine currently not available for UNICEF procurement
Vaccine currently not available for UNICEF procurement
Yes
Detailed pricing information for UNICEF and PAHO procurement can be found at: https://www.unicef.org/supply/documents/hepatitis-b-hepb-vaccine-price-data and https://www.paho.org/en/documents/revolving-fund-vaccine-prices-2026
Vaccine price ranges by product, procurement mechanism and income group as reported through the WHO/UNICEF JRF can be found at
Detailed pricing information for UNICEF and PAHO procurement can be found at: https://www.unicef.org/supply/documents/hepatitis-b-hepb-vaccine-price-data and https://www.paho.org/en/documents/revolving-fund-vaccine-prices-2026
Vaccine price ranges by product, procurement mechanism and income group as reported through the WHO/UNICEF JRF can be found at
Detailed pricing information for UNICEF and PAHO procurement can be found at: https://www.unicef.org/supply/documents/hepatitis-b-hepb-vaccine-price-data and https://www.paho.org/en/documents/revolving-fund-vaccine-prices-2026
Vaccine price ranges by product, procurement mechanism and income group as reported through the WHO/UNICEF JRF can be found at
Detailed pricing information for UNICEF and PAHO procurement can be found at: https://www.unicef.org/supply/documents/hepatitis-b-hepb-vaccine-price-data and https://www.paho.org/en/documents/revolving-fund-vaccine-prices-2026
Vaccine price ranges by product, procurement mechanism and income group as reported through the WHO/UNICEF JRF can be found at
Detailed pricing information for UNICEF and PAHO procurement can be found at: https://www.unicef.org/supply/documents/hepatitis-b-hepb-vaccine-price-data and https://www.paho.org/en/documents/revolving-fund-vaccine-prices-2026
Vaccine price ranges by product, procurement mechanism and income group as reported through the WHO/UNICEF JRF can be found at
1, World Health Organization. Prequalified vaccines. Geneva: WHO (https://extranet.who.int/prequal/vaccines/p/bevacr-1, https://extranet.who.int/prequal/vaccines/p/bevacr-2, accessed 23 September 2026).
2. Biological E. Limited. BEVAC: summary of product characteristics. (https://5.imimg.com/data5/SELLER/Doc/2024/9/450967656/FX/PD/IO/50761810/hepatitis-b-vaccine.pdf, accessed 23 September 2026).
1. World Health Organization. Prequalified vaccines. Geneva: WHO (https://extranet.who.int/prequal/vaccines/p/euvax-b-1, accessed 23
September 2026).
2. Ministry of Food and Drug Safety. MFDS to help Korean vaccine manufacturers go global: 14 domestic vaccines WHO PQ-certified (https://www.mfds.go.kr/eng/brd/m_60/view.do?seq=69836, accessed 30 July 2026).
3. European Medicines Agency. Hepatitis B vaccine (rDNA): List of nationally authorised medicinal products: PSUSA/00001597/202502 (https://www.ema.europa.eu/en/documents/psusa/hepatitis-b-vaccine-rdna-list-nationally-authorised-medicinal-products-psusa-00001597-202502_en.pdf, accessed 30 July 2026).
1. World Health Organization. Prequalified vaccines. Geneva: WHO. 2026 (https://extranet.who.int/prequal/vaccines/p/engerix-b, accessed 23 September 2026).
1. World Health Organization. Prequalified vaccines. Geneva: WHO. 2026
https://extranet.who.int/prequal/vaccines/p/heberbiovac-hb, accessed 23 September 2026).
1. World Health Organization. Prequalified vaccines. Geneva: WHO
(https://extranet.who.int/prequal/vaccines/p/hepatitis-b-vaccine-rdna-paediatric, accessed 23 September 2026).
* Please note that individual vaccine indications may differ
* Please note that individual vaccine indications may differ
* Please note that individual vaccine indications may differ
* Please note that individual vaccine indications may differ
* Please note that individual vaccine indications may differ
