HPV vaccines comparison
Export
Bivalent
Quadrivalent
Nonavalent
Cecolin
Cervarix
Walrinvax
Gardasil
CERVAVAC
Tsegardex
Gardasil 9
Cecolin 9

Xiamen Innovax Biotech

GlaxoSmithKline Biologicals

Walvax Biotechnonology

Merck Vaccines/MSD

Serum institute of India

Nanolel

Merck Vaccines/MSD

Xiamen Innovax Biotech

China

EMA

China

FDA

India

Russian Federation

FDA

China

2019

2007

2022

2006

2022

2025

2014

2025

2021

2009

2024

2009

Not prequalified by WHO

Not prequalified by WHO

2018

Not prequalified by WHO

HPV type 16 L1 protein - 40 μg, 
HPV type 18 L1 protein - 20 μg

HPV type 16 L1 protein - 20 μg, 
HPV type 18 L1 protein - 20 μg

0

HPV Type 6 L1 protein - 20 μg
HPV Type 11 L1 protein - 40 μg
HPV Type 16 L1 protein - 40 μg
HPV Type 18 L1 protein - 20 μg.

0

HPV Type 6 L1 protein
HPV Type 11 L1 protein 
HPV Type 16 L1 protein 
HPV Type 18 L1 protein

HPV Type 6 L1 protein - 20 μg
HPV Type 11 L1 protein - 40 μg
HPV Type 16 L1 protein - 40 μg
HPV Type 18 L1 protein - 20 μg
HPV Type 31 L1 protein - 20 μg
HPV Type 33 L1 protein - 20 μg
HPV Type 45 L1 protein - 20 μg
HPV Type 52 L1 protein - 20 μg
HPV Type 58 L1 protein - 20 μg

0

Eschericia Coli

Baculovirus

Pichia Pastoris

Yeast (Saccharomyces cerevisiae)

Hansenula polymorpha

Yeast (Saccharomyces cerevisiae)

Yeast (Saccharomyces cerevisiae)

Eschericia Coli

Aluminium hydroxide

AS04 (Aluminium hydroxide and 3-deacylated monophosphoryl lipid A)

Aluminium phosphate

Aluminium hydroxiphophate Sulphate

Aluminium hydroxide

Yes (not known)

Aluminium hydroxiphophate Sulphate

Aluminium hydroxide

None

None

None

None

None

None

None

None

Not required

Not required

Not required

Not required

Not required

Not required

Not required

Not required

Liquid: Ready to use

Liquid: Ready to use

Liquid: Ready to use

Liquid: Ready to use

Liquid: Ready to use

Liquid: Ready to use

Liquid: Ready to use

Liquid: Ready to use

1-dose glass (Type 1) vial (0.5ml)

1 or 2 dose glass (type 1) vial (0.5ml/dose)
Prefilled Syringe

1-dose vial (0.5ml)

1 dose vial (0.5ml/dose)
Prefilled Syringe

1 / 2 dose glass (type 1) vial (0.5ml/dose)

1 dose vial (0.5ml/dose)

1 dose vial (0.5ml/dose)

prefilled Syringe

1-dose glass (Type 1) vial (0.5ml)

Intramuscular

Intramuscular

Intramuscular

Intramuscular

Intramuscular

Intramuscular

Intramuscular

Intramuscular

36 months

60 months

36 months

36 months

24 months

no information available

36 months

36 months

2-8C

2-8C

2-8C

2-8C

2-8C

2-8C

2-8C

2-8C

Type 14

Type 30

Type 14

Type 30

Type 30

no information available

None

Type 14

14.29 (carton 10 vials)

One dose vial: 57.7cm3/dose (carton 1 vial) - 11.5 (carton 10 vials) - 9.7 (carton 100 vials)
Two doses vial: 28.8 (carton 1 vial) - 5.7 (carton 10 vials) - 4.8 cm3/dose (carton 100 vials)

11.8 cm3 (carton 20 vials)

74.7 (carton 1 vial)
15 (carton 10 vials)

no information available

no information available

18.4 (carton 10 vials UNICEF) 
15.11 (carton 10 vials PAHO)

(carton 10 vials)

Girls from 9 to 14 years of age: Two doses of 0.5 mL or three doses of 0.5mL.
Girls from 15 to 45 years of age: Three doses of 0.5 mL

Age 9 to and including 14 years - Two doses each of 0.5 ml.
From 15 years and above - Three doses each of 0.5 ml

Girls from 9 to 14 years of age: Two doses of 0.5 mL or three doses of 0.5mL.
Girls from 15 to 30 years of age: Three doses of 0.5 mL

Age 9 to and including 13 years - Two doses each of 0.5 ml.
From 14 years and above Three doses each of 0.5 ml

Age from 9 to 14 years: Two doses of 0.5 mL 
Age 15 to 26 years of age: Three doses of 0.5 mL

Age 18 to 45: Three doses of 0.5ml

Age 9 to and including 14 years - Two doses each of 0.5 ml.
From 15 years and above Three doses each of 0.5 ml

Girls from 9 to 17 years of age: Two doses of 0.5 mL or three doses of 0.5mL.
Girls from 18 to 45 years of age: Three doses of 0.5 mL

no information available

There are no safety, immunogenicity or efficacy data to support interchangeability of Cervarix with 
other HPV vaccines.

no information available

There are no safety, immunogenicity or efficacy data to support change during vaccination with
Gardasil to other HPV vaccines which do not cover the same HPV types.

It is recommended that individuals who receive a first dose of CERVAVAC® complete the vaccination course with CERVAVAC

no information available

Studies using a mixed regimen (interchangeability) of HPV vaccines were not performed for Gardasil 9.

no information available

not required

Not required

Not required

Not required

Not required

Not required

Not required

Not required

no information available

Cervarix is not recommended for use in children below 9 years of age due to limited data on safety 
and immunogenicity in this age-group.

no information available

The safety and efficacy of Gardasil in children below 9 years of age have not been established. No data are available.

The safety and efficacy of CERVAVAC® in children below 9 years of age have not been established. No data are available.

no information available

The safety and efficacy of Gardasil9 in children below 9 years of age have not been established. No data are available

no information available

YES

YES

YES

YES

NO

NO

YES

NO

1. World Health Organization (2023). Prequalified vaccines [online database]. Geneva: WHO (https://extranet.who.int/prequal/vaccines/prequalified-vaccines, accessed 19 June 2025).

1. European Medicines Agency (n.d.). Cervarix: EU summary of product characteristics [product information document]. Amsterdam: EMA (https://www.ema.europa.eu/en/documents/product-information/cervarix-epa…, accessed 19 June 2025).

1. World Health Organization (2023). Prequalified vaccines [online database]. Geneva: WHO (https://extranet.who.int/prequal/vaccines/prequalified-vaccines, accessed 19 June 2025).

1. European Medicines Agency (n.d.). Gardasil: EU summary of product characteristics [product information document]. Amsterdam: EMA (https://www.ema.europa.eu/en/documents/product-information/gardasil-epa…, accessed 19 June 2025).

1. Serum Institute of India (2025). Cervavac [website]. Pune: Serum Institute of India (https://www.seruminstitute.com/product_ind_cervavac.php, accessed 19 June 2025).

1. Nanolek website (2025) https://nanolek.ru/en/news/companynews/nanolek-received-a-registration-… (accessed on 1 July 2025)

1. European Medicines Agency (n.d.). Gardasil 9: EU summary of product characteristics [product information document]. Amsterdam: EMA (https://www.ema.europa.eu/en/documents/product-information/gardasil-9-e…, accessed 19 June 2025).

1. Xinhua News Agency (2025). China approves new domestically developed HPV vaccine. [website]. (https://english.news.cn/20250530/3c129f096e0842b2a2d4e43f82a190ca/c.html, accessed 19 June 2025).
2. Hu Y-M, Zhang X, Li Q, Wang J, Chen Y, Liu Z, et al. (2023). Immunogenicity and safety of an Escherichia coli-produced human papillomavirus (types 6/11/16/18/31/33/45/52/58) L1 virus-like-particle vaccine: a phase 2 double-blind, randomized, controlled trial. Sci Bull (Beijing). 68:2448–2455.