Yellow Fever Vaccine Booster Doses

What is currently recommended?

In 2009, the Advisory Committee on Immunization Practices (ACIP) approved yellow fever vaccine recommendations that noted International Health Regulations require revaccination at intervals of 10 years to boost antibody titer. Evidence from multiple studies demonstrates that yellow fever vaccine immunity persists for many decades and might provide life-long protection.

Why are the recommendations being modified now?

The World Health Organization Strategic Advisory Group of Experts in Immunization concluded in April 2013 that a single primary dose of yellow fever vaccine is sufficient to confer sustained immunity and lifelong protection against yellow fever disease, and a booster dose of the vaccine is not needed. In May 2014, the World Health Assembly adopted the recommendation to remove the 10-year booster dose requirement from the International Health Regulations by June 2016. Once the International Health Regulations are updated, the current statement in the ACIP recommendation will no longer be relevant.

What are the new recommendations?

A single primary dose of yellow fever vaccine provides long-lasting protection and is adequate for most travelers. The recommendations also provide considerations and recommendations for at-risk laboratory personnel and certain travelers to receive additional doses of yellow fever vaccine.