What is already known about this topic?

Rabies is a zoonotic infection that is nearly always fatal. Preexposure prophylaxis (PrEP) is recommended for certain persons at high risk for exposure.

What is added by this report?

During 2019–2021, the Advisory Committee on Immunization Practices made multiple updates to the rabies PrEP recommendations, including the following: a 2-dose (days 0 and 7) intramuscular rabies vaccination series replaced the 3-dose schedule, a one-time titer or booster dose was advised for persons with risk for only recognized rabies exposures, risk categories were redefined, and the minimum acceptable rabies antibody titer was changed to 0.5 IU/mL.

What are the implications for public health practice?

The updates are as efficacious as previous recommendations and might facilitate improved adherence to vaccination recommendations.

  • Recommendation
  • Americas
  • United States of America
  • Rabies