What is already known about this topic?

In 2015, the Advisory Committee on Immunization Practices (ACIP) recommended preexposure prophylaxis with ACAM2000, a replication-competent live virus Vaccinia virus vaccine, for certain U.S. persons at risk for occupational exposure to orthopoxviruses.

What is added by this report?

In 2019, JYNNEOS, a replication-deficient live Vaccinia virus vaccine was licensed in the United States. On November 3, 2021, ACIP voted to recommend JYNNEOS preexposure prophylaxis as an alternative to ACAM2000 for certain persons at risk for exposure to orthopoxviruses.

What are the implications for public health practice?

A second vaccine is now available for persons for whom vaccination against orthopoxvirus infections is recommended. Potential vaccinees should weigh the risks and benefits of each vaccine when deciding which to receive.

  • Recommendation
  • Americas
  • United States of America
  • Mpox // Monkeypox