What is already known about this topic?
Postexposure prophylaxis (PEP) with hepatitis A (HepA) vaccine or immune globulin (IG) prevents infection with hepatitis A virus when administered within 2 weeks of exposure. Measles, mumps, and rubella vaccine (MMR) is recommended for infants aged 6–11 months traveling outside the United States. IG cannot be administered simultaneously with MMR.
What is added by this report?
HepA vaccine is recommended for persons aged ≥12 months for PEP. Providers may also administer IG to adults aged >40 years, if indicated. The dosage of IG has been updated. Simultaneous administration of MMR and HepA vaccines is recommended for infants aged 6–11 months traveling internationally.
What are the implications for public health practice?
HepA vaccine for PEP provides advantages over IG, including induction of active immunity, longer duration of protection, ease of administration, and greater acceptability and availability.
- Recommendation
- Americas
- United States of America
- Hepatitis A
