At the October 2015 meeting of the Strategic Advisory Group of Experts (SAGE) on Immunization, SAGE recommended that an additional dose of measles-containing vaccine be administered to HIV-infected children receiving highly active antiretroviral therapy (HAART) following immune reconstitution. In considering this recommendation, SAGE requested evidence on the need for revaccination of HIV-infected adolescents and adults. This report summarizes the available evidence and provides the basis for policy recommendations.
For the purposes of this review, HIV-infected adolescents and adults refer to individuals not infected through mother-to-child HIV transmission. Although an increasing number of perinatally-infected children are surviving into adolescence and adulthood, HIV infection commonly precedes exposure to measles vaccine or wild-type virus in these individuals. Consequently, immune responses to measles vaccine develop in the context of a compromised immune system. This temporal sequence is inverted in HIV-infected adolescents and adults who acquire HIV infection later in life through sexual or other modes of HIV transmission after exposure to measles vaccine virus. This latter group of HIV-infected adolescents and adults is the focus of this review.
- GRADE table
- Measles
