This statement will supplement previous pneumococcal statements and provide the evidence used to determine the optimal time between initial vaccination with polysaccharide 23-valent pneumococcal vaccine (Pneu-P-23) and subsequent booster doses to protect against IPD in those at highest risk for IPD.
Individuals who are 2 years of age and over and at high risk for IPD, as defined in the Canadian Immunization Guide (CIG) (http://www.phac-aspc.gc.ca/publicat/cig-gci/p04-pneu-eng.php), are recommended to receive Pneu-P-23 vaccine, in addition to age and risk-specific recommendations for the conjugate 13-valent pneumococcal vaccine (Pneu-C-13). Age and risk-specific recommendations and schedules for these vaccines are outlined in the CIG.
NACI currently recommends re-immunization with one life-time booster dose of Pneu-P-23 for those 2 years of age and older at highest risk of IPD. Individuals included in the group at highest risk of IPD are those with functional or anatomic asplenia or sickle cell disease; hepatic cirrhosis; chronic renal failure or nephrotic syndrome; HIV infection; and immunosuppression related to disease or therapy. Currently, for these groups, a single re-immunization after 5 years is recommended in persons who were 11 years of age or over at the time of initial immunization with Pneu-P-23 vaccine. A single re-immunization after 3 years is recommended for those who were 10 years of age or younger at the time of initial immunization with Pneu-P-23 vaccine. Because there are insufficient data to recommend repeated administration of Pneu-P-23 vaccine, re-vaccination following a second dose is not routinely recommended.
This update will:
- Provide a systematic review of the literature on booster doses of pneumococcal vaccine for individuals at high risk of IPD disease.
- Make recommendations for booster doses of pneumococcal vaccine.
- Recommendation
- Americas
- Canada
- Pneumococcal disease
