Menstrual Disorders Following Covid 19 Vaccination in Women of Reproductive Age and Post-Menopause. A Systematic Review

Background: During the coronavirus pandemic, several factors such as stress, depression, infection, and vaccination against the COVID-19 virus have caused changes in the menstrual cycle. Objective & Aims: This systematic review intended to provide a comprehensive interpretation of the changes in the menstrual cycle of women of reproductive age and menopause after coronavirus vaccination. Method(s): Electronic databases, including Web of Science, PubMed, Scopus, ScienceDirect, ProQuest, Cochrane, SAGE, Springer, Google Scholar, and CINHAL were searched for published studies from March 2020 to June 2023. Of the 682 references identified in the initial search, 27 studies met the inclusion criteria. Result(s): The results of this systematic review showed that COVID-19 vaccination is associated with a wide range of menstrual disorders in women of reproductive age and postmenopausal women. The most commonly reported disorders were menorrhagia, delayed menstruation, changes in menstrual cycle length, spotting between periods, and increased bleeding volume. In postmenopausal women, complications such as spotting and resumption of bleeding were also observed. Although the prevalence and incidence of each disorder varied across studies, these findings suggest that vaccination can lead to changes in the menstrual cycle. Conclusion(s): COVID-19 vaccination may lead to menstrual disorders in women of reproductive and postmenopausal age, which can cause concern and reduce social and psychological quality of life. However, these effects are usually temporary and transient, resolving after a few menstrual cycles. Further studies are needed to investigate the possible mechanisms of this association and identify associated risk factors. Copyright © 2025 The Author(s). Health Science Reports published by Wiley Periodicals LLC.