Knowledge, awareness and acceptability of anti-HPV vaccine in the Arab states of the Middle East and North Africa Region: a systematic review

Background: Rapid changes in lifestyle induced by globalization have brought about changes in sexual behaviour, especially among younger generations. These changes may lead to considerable consequences on the prevalence of sexually transmitted disease, including human papillomavirus (HPV) infection. Aims: The objective of this study is to provide a systematic review of peer-reviewed literature on human papillomavirus (HPV) vaccine awareness and acceptability in the Arab states of the Middle East and North Africa region. Methods: A systematic search was conducted across 2 electronic databases: PubMed and EMBASE, to identify studies related to HPV vaccination awareness and acceptability in the region between January 2010 and April 2017. Results: Eighteen studies from 9 countries were identified. The analysis showed low to moderate HPV infection knowledge and anti-HPV vaccine awareness. Nevertheless, most studies reported moderate to high anti-HPV vaccine acceptability among subpopulations. Broad gaps in knowledge and willingness were highlighted regarding HPV vaccine acceptability. Conclusions: An examination of the region collectively offers an insight into the willingness of the general population and healthcare providers to receive more information about the virus and prevention of infection through vaccination. This review suggests that the vaccine acceptability would be high once cost concerns are resolved.