GRADE and Evidence to Recommendation tables on RTS,S/AS01 malaria vaccine

Question: Should a minimum of 4 doses of RTS,S/AS01 be provided to reduce malaria disease burden in children >= 5 months of age living in countries in subSaharan Africa with moderate to high malaria transmission?

Population: Children ≥ 5 months of age living in countries in sub-Saharan Africa with moderate to high malaria transmission

Intervention: A minimum of 4 doses of RTS,S/AS01 (given as a 3-dose initial series; first dose should be provided between 5 and 17 months of age) with a minimal interval between doses of 4 weeks

Comparison: Malaria interventions currently in place without malaria vaccination

Setting: countries in sub-Saharan Africa with moderate to high malaria transmission