Dengue Evidence to Recommendation

Policy question: Should the TAK-003 vaccine be recommended over no vaccination to immunocompetent individuals 6 years and older in dengue endemic countries to reduce the burden of dengue? 

Population: Immunocompetent individuals (≥6 years of age)

Intervention: Two doses of TAK-003 

Comparison(s): No vaccination 

Outcomes: Symptomatic (virologically confirmed) dengue illness, hospitalized dengue, and severe dengue