Coronavirus disease -2019 (COVID-19) is an ongoing pandemic that affected around 27 million confirmed cases of COVID-19, including more than 5 million deaths. However, on 24th November 2021, the world health organization (WHO) announced a new SARS-CoV-2 variant designated as the B.1.1.529 a variant of concern (VOC) and the variant has been named as "Omicron". Available preliminary evidence suggests that, as compared to previous VOCs, it has an increased risk of infectivity. Studies have shown that protection from various vaccines effectiveness against hospitalization and death from severe COVID-19 disease is decreasing slowly after a two-dose schedule of COVID-19 vaccines. In response to experiencing a new COVID-19 variant and ongoing resurgence of cases importance of COVID-19 vaccine booster dose and durability of the effect of the third dose of vaccine against Covid-19 Omicron variant is controversial yet. Hence here we have done a systematic search in Pub Med, Google Scholar and MedRXiv database, from inception to January 2022 using the MeSH terms and keywords "Corona Virus Disease-2019 OR COVID-19 AND Omicron AND COVID-19 Booster Vaccine". We have identified a total of 21 published studies. We have reviewed all the eligible available studies on the effectiveness of the COVID-19 vaccine booster shots against the Omicron variant. This article is protected by copyright. All rights reserved.

  • Adults (18+)
  • Elderly (65+)
  • Vaccine/vaccination
  • Efficacy/effectiveness
  • COVID-19