BCG vaccination at birth vs. at 6 weeks

Question: Should the BCG vaccine be given to infants at birth or at the time of the first dose of the diphtheria tetanus and pertussis (DTP1) containing vaccine at 6 weeks of age to mitigate the risk of severe TB disease, with special focus on countries with a high burden of TB?

• Population: Infants.
• Intervention: One dose of BCG vaccine given at birth.
• Comparison(s): One dose of BCG vaccine given at the same time as the first dose of DTP vaccine at the age of 6 weeks.
• Outcome: Prevention of severe TB disease in childhood (miliary, meningeal form ) and TB associated death