RSV vaccines comparison
Monoclonal antibodies
Vaccines
Beyfortus (Nirsevimab)
Enflonsia (Clesrovimab)
Abrysvo (RSVpreF)
Arexvy (RSVPreF3-AS01)
Sanofi
Merck / MSD
Pfizer
GlaxoSmithKline
EMA
FDA
FDA
FDA
11/04/2022
06/09/2025
03/31/2023
03.05.2023
07/17/2023
06/09/2025
03/31/2023
03.05.2023
11/04/2022
N/A
08/24/2023
06/06/2023
N/A
N/A
03/12/2025
N/A

fully human IgG1κ monoclonal antibody targeting prefusion RSV F protein

fully human IgG1κ monoclonal antibody targeting prefusion RSV F protein

RSV subgroup A prefusion F antigen 60 μg
RSV subgroup B prefusion F antigen 60 μg

RSV Prefusion F3 antigen
recombinant Chinese Hamster Ovary cells
recombinant Chinese Hamster Ovary cells
recombinant Chinese Hamster Ovary cells
recombinant Chinese Hamster Ovary cells

None

None

None

AS01

None

None

None

None
Not required
Not required
Water for injections
Water for injections
Liquid ready to use
Liquid ready to use
Powder
Powder

Glass (Type 1) pre-filled syringe containing 50 mg of nirsevimab in 0.5 mL (100 mg/mL) or containing 100 mg of nirsevimab in 1 mL (100 mg/mL).

Glass (Type 1) pre-filled syringe containing 105 mg of clesrovimab in 0.75 mL

Powder for 1 dose in a vial (type 1 glass or equivalent)
Solvent for 1 dose in a pre-filled syringe (type 1 glass) / vial (type 1 glass or equivalent)

Powder for 1 dose in a vial (type I glass)
Suspension for 1 dose in a vial (type I glass)
intramuscular
intramuscular
intramuscular
intramuscular
24 months EU / 18 months US
30 months
3 years
3 years
2-8C
2-8C
2-8C
2-8C
N/A
N/A
N/A
N/A

Single dose in carton of 1
Single dose in carton of 5

Single dose in carton of 1
Single dose in carton of 10

12.1 cm3/dose in the 25 doses pack

?

Single dose of 50 mg administered intramuscularly for infants with body weight <5 kg and a single dose of 100 mg administered intramuscularly for infants with body weight ≥5 kg. Beyfortus should be administered from birth for infants born during the RSV season. For others born outside the season Beyfortus should be administered ideally prior to the RSV season.

A single dose of 200 mg given as two intramuscular injections (2 x 100 mg) for children who remain vulnerable to severe RSV disease through their second RSV season. Beyfortus should be administered ideally prior to the start of the second RSV season

Single 105 mg IM dose administered to neonates and infants who are born during or entering their first RSV season.
Infants born during season: dose at birth.
Born before season: dose before season starts.

Additional 105 mg dose recommended post cardiac bypass surgery

Pregnant women - A single dose of 0.5 mL should be administered between weeks 24 and 36 of gestation 
Individuals 18 years of age and older - a single dose of 0.5 mL should be administered.

Adults older than 50 (if at risk of RSV) or older than 60 in single dose of 0.5 mL.
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A

The benefits and risks of nirsevimab use in infants <1 kg should be carefully considered.
There are limited data available in extremely preterm infants (Gestational Age [GA] <29 weeks) less than 8 weeks of age. No clinical data available in infants with a postmenstrual age (gestational age at birth plus chronological age) of less than 32 weeks

The safety and efficacy of nirsevimab in children aged 2 to 18 years have not been established. No 
data are available

Can be given alongside routine childhood vaccines, in different syringes & sites
The safety and effectiveness of ENFLONSIA have not been established in children older than 12 months of age.

The safety and efficacy of Abrysvo in children (from birth to less than 18 years of age) have not yet been established. Limited data are available in pregnant adolescents and their infants

The safety and efficacy of Arexvy in children have not been established
NO
NO
NO
NO

Detailed pricing information for PAHO procurement can be found at: https://www.paho.org/en/documents/revolving-fund-vaccine-prices-2025

Detailed pricing information for PAHO procurement can be found at: https://www.paho.org/en/documents/revolving-fund-vaccine-prices-2025

Detailed pricing information for PAHO procurement can be found at: https://www.paho.org/en/documents/revolving-fund-vaccine-prices-2025

Detailed pricing information for PAHO procurement can be found at: https://www.paho.org/en/documents/revolving-fund-vaccine-prices-2025

1. European Medicines Agency (n.d.). Beyfortus: EU summary of product characteristics [product information document]. Amsterdam: EMA (https://www.ema.europa.eu/en/documents/product-information/beyfortus-ep…, accessed 19 June 2025).

1. U.S. Food and Drug Administration (2025). ENFLONSIA™ (clesrovimab-cfor) injection, for intramuscular use: Highlights of prescribing information. Silver Spring, MD: FDA (https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/761432s000lbl…, accessed 19 June 2025).

1. European Medicines Agency (n.d.). Abrysvo: EU summary of product characteristics [product information document]. Amsterdam: EMA (https://www.ema.europa.eu/en/documents/product-information/abrysvo-epar…, accessed 19 June 2025). 

2. World Health Organization (n.d.). Abrysvo [online database]. Geneva: WHO (https://extranet.who.int/prequal/vaccines/p/abrysvo, accessed 19 June 2025).
N/A