SAGE/MPAC evidence to recommendations table on the use of malaria vaccines

Question: Should 4 doses of RTS,S/AS01 be introduced into national immunization programs of countries in Sub-Saharan Africa with medium-high malaria parasite transmission?

• Population: Children ≥5 months in Sub-Saharan Africa
• Intervention: 4 doses of RTS,S/AS01 (given as a 3-dose initial series with a minimum interval between doses of 4 weeks, followed by a 4th dose at 15–18 months following the 3rd dose to children as close as possible to the age of 5 months) in context of implemented other malaria prevention methods (e.g. long-lasting insecticide-treated nets), rapid diagnosis and effective treatment.
• Comparison(s): No vaccination in context of implemented other malaria preventive methods (e.g. long-lasting insecticide-treated nets), rapid diagnosis and effective treatment.
• Outcome: Occurrence of severe malaria caused by P. falciparum.