Efficacy of anti-RSV vaccination in preventing respiratory syncytial virus disease and severe illness in older adults: a systematic review of randomized controlled trials

Aim: We aimed to understand the efficacy of RSV vaccines in preventing RSV disease and severe illness in older adults. Finding(s): Prefusion type vaccines are efficacious in the prevention of RSV-related acute respiratory infection and lower respiratory tract disease. More positive results are found when analyzing the already commercialized vaccines alone. Message: RSVPreF3 OA is the only vaccine with results for the prevention of severe disease, therefore preventing hospitalization and the need of oxygen therapy or ventilation. More studies are necessary in the future on this matter. Copyright © The Author(s), under exclusive licence to European Geriatric Medicine Society 2024.