What is already known about this topic?
Hepatitis A (HepA) vaccine is highly safe and effective, and a complete HepA vaccine series provides long-term protection against hepatitis A virus (HAV) infection. Person-to-person HAV outbreaks among persons using drugs or experiencing homelessness are widespread and ongoing.

What is added by this report?
All persons aged ≥1 year experiencing homelessness should be routinely immunized against HAV. Vaccination of homeless persons facilitates integration of HepA vaccine into routine preventive services.

What are the implications for public health practice?
HepA vaccination of homeless persons would improve protection of persons at increased risk of exposure to HAV and complications of hepatitis A disease and reduce the risk for large-scale outbreaks by increasing immunity to HAV among homeless persons living in congregate settings where HAV can spread readily.

Recommendation Americas United States of America