Rotavirus is a highly contagious disease that causes vomiting and diarrhoea. Young children in particular may become seriously ill and develop dehydration symptoms for which they need to be treated in hospital. There are two oral vaccines against rotavirus on the market. At the request of the Minister of Health, Welfare and Sport, the Committee on Vaccinations of the Health Council of the Netherlands has evaluated vaccination of children against rotavirus. In any case, the Committee recommends vaccinating children with a risk factor (prematurity, low birth weight or congenital abnormality). The Committee also welcomes the inclusion of vaccination against rotavirus in the National Immunisation Programme, bearing in mind, however, that the cost effectiveness of vaccination is unfavourable based on the asking prices of the vaccines.