Abstract

Objective 
To evaluate the efficacy and security of using HBIG alone or combined with hepatitis B vaccine to interrupt transmission of HBV in uterus to fetus during antepartum period of pregnant women with HbsAg positive.
Methods 
Six electronic databases and nine kinds of related journals were searched.In addition,the eligible references were searched.Randomized controlled trials or qusi-randomise controlled trials comparing hepatitis B immunoglobulin(HBIG) or HBIG combining with hepatitis B vaccine with no or other intervention in HBsAg positive pregnant women were eligible for inclusion.Two investigators independently assessed the quality and extracted the data.Meta-analysis was performed by software Revman 4.2.10.Heterogeneity was examined by Chi-square test.Fixed and random effect meta-analysis was used to pool the data.
Results 
It was found by meta-analysis that,compared with no intervention,HBIG(600 IU) for the HBsAg positive/HBsAg and HBeAg double positive pregnant women could decrease the rate of intrauterine infection(RR=0.42,95%CI=0.21-0.83,P=0.01) and the positive rate of HBV DNA of the newborn(RR=0.30,95%CI=0.10-0.85,P=0.02) significantly,but could not decrease the positive rate of HBeAg and Anti-HBs of the newborn significantly.HBIG(600 IU) for the HBsAg positive/HBsAg and HBeAg double positive pregnant women could decrease the rate of intrauterine infection(RR=0.39,95%CI=0.26-0.58,P0.000 01) and could not for the positive rate of Anti-HBs of the newborn significantly.There is no significantly statistical difference in the rate of intrauterine infection and the positive rate of HBeAg and HBV DNA and Anti-HBs of the newborn compared with no intervention when HBIG(600 IU) for the HBsAg and HBeAg double positive pregnant women;while when the total dose of HBIG is 600 IU,it is reported that the positive rate of HBeAg and HBV DNA of the newborn could be decreased significantly.
Conclusion 
HBIG for the HBsAg positive/HBsAg and HBeAg double positive pregnant women can decrease the rate of intrauterine infection.But the effect of HBIG for HBsAg and HBeAg double positive pregnant women to interrupt intrauterine infection is not clear.


Journal of Pathogen Biology, 90-95, 3, 2

Hepatitis B