WHO issues updated positon paper on yellow fever vaccine

23 June 2017

In a revised yellow fever (YF) vaccine position paper published in today’s edition of the Weekly Epidemiological Record, WHO provided updated guidance on the use of fractional dose YF vaccination in the context of YF vaccine supply shortages.


Recent outbreaks have highlighted the critical importance of strong routine YF immunization programmes and mass vaccination campaigns in line with the WHO Eliminate Yellow Fever Epidemics (EYE) Strategy for the prevention of YF outbreaks.

A fractional YF vaccine dose can be used as part of an emergency response to an outbreak if there is a shortage of full-dose YF vaccine that exceeds the capacity of the global stockpile. This is not intended to serve as a longer-term strategy or to replace established routine immunization practices.

Administration of fractional dose YF vaccine constitutes an off-label use of the vaccine. Preference should be given to YF vaccine products for which immunogenicity and safety data are available on a fractional dose administered subcutaneously or intramuscularly.

As soon as the YF vaccine supply situation can meet the immediate need, the use of fractional dose YF vaccination should be replaced by standard full-dose YF vaccination.

Documents to download

Related News & Events

  • Africa

    Call for Nominations of experts


    The WHO Regional Office for Africa is soliciting proposals for nominations for current vacancies on its Regional Immunization Technical Advisory Group (RITAG). Nominations are required to be submitted no later than 04 September 2017.  Nominations will be carefully reviewed by the RITAG membership selection panel which will propose the selection of nominees for appointment to the WHO Regional Director for Africa.

    Read more
  • Europe

    First day of the Programme Managers Meeting


    The meeting of National Immunization Programme Managers is currently being held in Antwerp from 1st to 3rd September, 2015.  Robb Butler, Programme Manager at WHO EURO, opened the meeting with Professor Pierre Van Damme, Chair of the European Technical Advisory Group of Experts on Immunization (ETAGE).

    Read more
  • WHO

    The 2015 PAHO TAG Report has been published


    The XXIII Meeting of the Technical Advisory Group (TAG) on Vaccine‐preventable Diseases of the Pan American Health Organization (PAHO) was held in Varadero, Cuba on 1-3 July 2015.The slogan for the meeting was “Bye-bye rubella! Let’s go for more!” selected in recognition of the recent certification of the regional elimination of rubella and Congenital Rubella Syndrome (CRS). The objectives of this meeting were to present the Regional adaptation of the Global Vaccine Action Plan (GVAP), to review progress on several disease elimination and control initiatives and issue recommendations to address the many challenges faced by national immunization programs in the Americas. 

    Read more